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Description

The results have been consistent across dozens of high-quality rat studies that researchers got very excited

The intranasal route is particularly relevant for CNS-targeted research with these compounds, as it facilitates delivery via the olfactory and trigeminal nerve pathways to the CNS, bypassing the blood-brain barrier

Fluids Barriers CNS 18(1):7 Maiuolo J, Gliozzi M, Musolino V, Scicchitano M, Carresi C, Scarano F et al (2018) The frail brain blood barrier in neurodegenerative diseases: role of early disruption of endothelial cell-to-cell connections